Treatment for low grade squamous intraepithelial lesion

Qué es la lesión intraepitelial escamosa de bajo grado leibg

Sesenta pacientes, 27% seropositivos, fueron sometidos a vigilancia durante una mediana de 42 (rango 7-240) meses de seguimiento. Siete habían tenido una recurrencia local previa al entrar en el estudio, por lo que se analizaron por separado. Treinta de los 53 fueron sometidos a quimiorradiación (57%) y 23 de los 53 fueron sometidos sólo a escisión (43%); 33 tenían cáncer perianal y 20 cáncer anal. Diez de 30 del grupo de quimiorradiación tenían enfermedad en estadio 1 (33%) en comparación con 22 de 23 del grupo de sólo escisión (96%, p < 0,001).

Se detectaron lesiones intraepiteliales escamosas de alto grado en 4 de 30 (13%) pacientes tras la quimiorradiación y en 17 de 23 (74%) pacientes tras la escisión solamente (p < 0,001). Veinte de 21 (95%) lesiones de alto grado fueron tratadas con ablación. Seis de 7 (86%) pacientes con recidiva local previa tenían lesiones intraepiteliales escamosas de alto grado durante una mediana de 21 meses de seguimiento. Una recidiva local (T1N0M0) se produjo durante la vigilancia después de la quimiorradiación primaria (0,56/1000 personas-mes), ninguna se produjo después de la escisión solamente, y 2 de 7 con recidiva local previa desarrollaron otra recidiva local (6,86/1000 personas-mes). Las 3 recidivas locales se produjeron tras el tratamiento de lesiones intraepiteliales escamosas de alto grado. No hubo metástasis, escisiones abdominoperineales ni muertes por carcinoma escamoso anal.

  Tensor de la fascia lata lesion ciclismo

Cervical neoplasia

Human papillomavirus (HPV) is a virus that can infect the skin (cutaneous HPV) and mucous membranes (mucosal HPV). More than 200 different types have been identified, of which about 40 are capable of infecting the genital and anal mucosa of both sexes. Mucosal HPVs are subdivided into:

HPV is transmitted by skin or mucosal contact. The main route of transmission is sexual (by vaginal and/or anal penetration and less frequently by skin-to-skin contact in the genital area and by oral sex). Any sexually active person who has genital contact (even without penetration) with another person infected with HPV can become infected. In fact, HPV is the most common sexually transmitted infection worldwide.

Other epithelia of the ano-genital area (such as the vagina, vulva, anus, penis) or extragenital area (such as the oropharynx or larynx) are less susceptible, but can also undergo a similar process with the appearance of premalignant-malignant lesions.

Treatment for squamous intraepithelial lesions

Descriptive cross-sectional study of a series of cases, including 122 treated women, 79 (65%) for low-grade SIL (LSIL) and 43 (35%) for high-grade SIL (HSIL) who attended the HPV Laboratory of the Health Sciences Research Institute, National University of Asuncion, for a post-treatment control, period 2006/2010.

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A total of 28% (34/122) of women treated for SIL were positive for HR-HPV, with viral infection detected in 20% of women with absence of SIL (NSIL) (22/108), 83% of women with LSIL (10/12) and 100% of women with HSIL (2/2). Of the 34 women positive for HR-HPV, 10 women (29%) presented high values (100 pg/mL or more) of relative viral load, detecting an increase of positive cases with the severity of the lesion (28% NSIL, 30% LSIL, 50% HSIL).

The detection of HR-HPV by CH II(r), as well as high relative viral load values, especially in women with NSIL could help identify treated women at risk of developing recurrences, thus contributing to strengthen the cervical cancer prevention program.

Nic 1 can be cured

NSAIDs have been found to prevent the development of cancer of the large bowel and other organs, but with some undesirable side effects, especially on the heart and blood vessels. Although rofecoxib, used in one of these studies, was withdrawn from the market in 2004, it may shed light on the feasibility of treatment with other NSAIDs.

The objective of the review was to discover whether administration of NSAIDs to patients with CIN could promote regression or prevent progression to cervical cancer without excessive risks or side effects.

The studies appear to have been well conducted. There are some questions related to the quality of evidence regarding concealment and dropout of the study by women before completing the assigned drugs. Therefore, it was concluded that the certainty (quality) of the evidence was moderate. There was insufficient information to assess the accuracy of reporting. There may be other incomplete and unreported studies that were not identified.

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